TRPV2 and neoplasm: To investigate biological distributions of nanoparticles and quantify TRPV2 targeting effects in vivo, indocyanine green (ICG)-encapsulated PCHN or TRPV2–PCNH nanocomplexes were intravenously injected into mice bearing two tumours on opposite flanks, which were derived from HT-29 cells and TRPV2 derivative cells, respectively.