Interestingly, we found that in a murine model of sterile peritonitis, both NSlit2 and a pharmacologic inhibitor of macropinocytosis, EIPA, attenuated the MDP-induced CXCL1 secretion, locally in the peritoneal exudate (Supplementary Fig. 5b), and systemically in serum (Fig. 5e, f). Here, CXCL1 is linked to peritonitis.