Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif2a∆/∆ tumours showed greater enrichment of a number of different immune cell signatures when compared to Vhl∆/∆Trp53∆/∆Rb1∆/∆ tumours and to Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif1a∆/∆ tumours, including several types of T cells, monocytes, and macrophages, and notably for interferon-γ signalling (REACTOME.IFNG), consistent with the previous GAGE analyses. This evidence concerns the gene IFNG and neoplasm.