Other HIF-2α-dependent GAGE terms that might be relevant to the evolution and proliferation of Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif2a∆/∆ tumours included genes that are targets of the MYC and E2F transcription factors, consistent with previous studies showing that HIF-2α promotes the activity of the MYC transcription factor21. Here, MYC is linked to neoplasm.