Interestingly, we demonstrated not only in Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif2a∆/∆ tumours but also in Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif1a∆/∆ tumours that the density of intra-tumoural CD8+ T cells were approximately double the density in Vhl∆/∆Trp53∆/∆Rb1∆/∆ tumours. The gene discussed is CD8A; the disease is neoplasm.