We previously demonstrated that Vhl∆/∆Trp53∆/∆Rb1∆/∆ tumours show upregulation of numerous cytokines in comparison to WT cortex16, however analyses of the new dataset did not reveal any cytokines that were specifically altered by the absence of HIF-1α or HIF-2α (Supplementary Fig. 12a) that might be expected to influence T-cell infiltration or activation. The gene discussed is EPAS1; the disease is neoplasm.