CD3D and neoplasm: To investigate whether HIF1A loss correlates with altered inflammation, we first demonstrated that HIF1A loss tumours exhibit on average between 1.9- and 2.1-fold higher levels of mRNA of CD3D, CD3E, CD8A, and CD8B and 1.4-fold higher levels of CD4 than unaltered tumours (Fig. 7d, f, h, j, l), suggesting that this group of tumours has higher CD8+, and to a lesser extent CD4+, T-cell infiltration.