Interestingly, genes that were upregulated in HIF-2α-deficient tumours include those enriched in diverse GAGE terms for interferon signalling, T-cell activation, innate immunity, adaptive immunity, antigen processing and presentation, and NF-κB as well as IRF transcription factor targets, suggestive of an altered immune environment in these tumours. This evidence concerns the gene EPAS1 and neoplasm.