Finally, it is also noteworthy that HIF1A copy loss and HIF2A mRNA high tumours showed opposite effects on signatures for pericytes, endothelial cells and angiogenesis, implying that both HIF-1α and HIF-2α may act as positive factors that promote blood vessel formation in ccRCC tumours. This evidence concerns the gene EPAS1 and nonpapillary renal cell carcinoma.