Consistent with HIF-2α deficient tumours showing the highest GAGE mRNA signatures of T-cell inflammation, Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif2a∆/∆ tumours displayed increased densities of CD3 (Fig. 6b), CD4 (Fig. 6c), and CD8 (Fig. 6d) positive T cells compared to normal tissue, whereas only CD8 positive T-cell densities were significantly increased in Vhl∆/∆Trp53∆/∆Rb1∆/∆ and Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif1a∆/∆ tumours compared to the respective normal tissues. This evidence concerns the gene EPAS1 and neoplasm.