We focused analyses on genes that were differentially expressed between Vhl∆/∆Trp53∆/∆Rb1∆/∆ tumours and the Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif1a∆/∆ and Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif2a∆/∆ tumour genotypes and identified 396 differentially expressed genes that are dependent on HIF-1α (Supplementary Fig. 7a), 804 differentially expressed genes that are dependent on HIF-2α (Supplementary Fig. 7b) and 131 differentially expressed genes that are dependent on both HIF-1α and HIF-2α (Supplementary Fig. 7c). This evidence concerns the gene HIF1A and neoplasm.