We additionally analysed RNA-sequencing data (see experiments described below) which showed that Vhl∆/∆Trp53∆/∆Rb1∆/∆ tumours displayed lower mRNA levels of Hif1a and Hif2a than WT cortex but that there was no compensatory upregulation of Hif2a in Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif1a∆/∆ tumours, nor of Hif1a in Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif2a∆/∆ tumours (Supplementary Fig. 3a, b). The gene discussed is EPAS1; the disease is neoplasm.