Analyses of the expression levels of the mouse orthologues of this set of HIF-2α target genes revealed that many of these genes are highly upregulated in Vhl∆/∆Trp53∆/∆Rb1∆/∆ tumours compared to WT cortex, but that the loss of either HIF-1α or HIF-2α did not broadly affect the upregulation of these genes (Supplementary Fig. 7d). This evidence concerns the gene EPAS1 and neoplasm.