Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif1a∆/∆ tumours in comparison to Vhl∆/∆Trp53∆/∆Rb1∆/∆ and Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif2a∆/∆ tumours show low expression of glycolytic genes (Fig. 3b), as well as signatures associated with hypoxia and known HIF-1α targets. The gene discussed is HIF1A; the disease is neoplasm.