Notably, both Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif1a∆/∆ and Vhl∆/∆Trp53∆/∆Rb1∆/∆Hif2a∆/∆ tumours exhibited higher densities of CD8 positive T cells than Vhl∆/∆Trp53∆/∆Rb1∆/∆ tumours, in line with the Bindea et al. ssGSEA CD8 T-cell signature results. This evidence concerns the gene CD8A and neoplasm.