IGFBP1 and systemic sclerosis: However, the gender seems having an impact on the levels of the combined model with Nu.Q H3.1, IGFBP-1, and MMP-9 only in the SSc-ILD group: a two-way ANOVA showed an interaction between the gender and the disease (p = 0.027) on the probability of SSc-ILD provided by the model (Supplementary Figure 2).