In this study, we investigated whether there was an association between the level of circulating H3.1 containing nucleosomes and other biomarkers of interest in systemic sclerosis or lung fibrosis such as the serum growth factors IGFBP-1 and the MMP enzyme MMP9, as a suitable approach or the correct identification of SSc-ILD disease [14–19]. This evidence concerns the gene IGFBP1 and pulmonary fibrosis.