It is gratifying that in recent years, an increasing number of biomarkers for the diagnosis of PJI have been found, including synovial quantitative alpha-defensin, serological white blood cell count (WBC), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) interleukin-6 (IL-6), and procalcitonin [29]. The gene discussed is IL6; the disease is juvenile polyposis syndrome.