To explore the possibility of selectively killing tumor cells with high mTORC1 activity, we performed bioinformatic analysis using various tumor cells including TSC1 and TSC2-deficient cells (GEO accession number GSE16944 [15], GSE21755 [16], GSE5332 [17], GSE27982 [18], GSE28021 [18], GSE67529, GSE28992 [19], GSE18571 [20], GSE7344 [21], GSE37129 [22] and GSE17662 [23]) (Fig. 1a). The gene discussed is TSC1; the disease is neoplasm.