Taken together, the opposite action of AT1 and AT2 receptors, their expression in microglia, and the marked upregulation of AT1/2Hets lacking cross-antagonism but displaying antagonist-mediated cross-potentiation suggest that interventions aimed at antagonizing central AT1Rs to potentiate AT2R-mediated actions may be beneficial in PD. Here, AGTR2 is linked to Parkinson disease.