HMGCR and metabolic dysfunction-associated steatotic liver disease: Although recent study suggested that the role in treating NAFLD has been partially elucidated as the regulation of lipid metabolism related SREBP-1c, FAS and SCD1 [14], the mechanism for regulating TC metabolism are still unclear, we speculate that it may be related to the synthesis and secretion of cholesterol regulated by SREBP2 and HMGCR.