BRCA2 and ovarian cancer: However, several factors associated with an increased risk of ovarian cancer have been identified: age, number of ovulations (early menarche, infertility, low parity), the use of hormone replacement therapy (HRT) [10], obesity, physical inactivity, a family history of breast and ovarian cancer, including BRCA1 and BRCA2 gene mutations [11], and past and current smoking [12].