To gain a deeper understanding of the tumor suppressor functions of SOCS1 and SOCS3 in HCC, and to identify the signaling pathways that are aberrantly activated in the absence of SOCS1 or SOCS3, we carried out a systematic analysis on the TCGA dataset on liver HCC (TCGA-LIHC) [6]. This evidence concerns the gene SOCS3 and neoplasm.