As shown in Supplementary Figure S2, Cxcl1, Cxcl2 and Cxcl5 genes showed significantly elevated expression in the regenerating livers of mice lacking SOCS3 or SOCS1, whereas Cxcl1 was upregulated and Cxcl2 and Cxcl5 were downregulated in DEN-induced HCC tissues of both mice compared to control mice. The gene discussed is SOCS1; the disease is hepatocellular carcinoma.