As SOCS1 and SOCS3 are implicated in the regulation of HGF, EGF and IL-6 signaling that promote hepatocyte proliferation and HCC pathogenesis [17, 22, 26, 27], we first evaluated the relationship between the expression of SOCS1 and SOCS3 with the cell cycle regulation genes. This evidence concerns the gene SOCS3 and hepatocellular carcinoma.