In contrast to Aurka, Mlst8 and Map 3 k4, which are negatively correlated with SOCS3 in the TCGA dataset, were not affected by SOCS3 deficiency in the regenerating livers or in HCC tissues, although discernible upregulation of Mlst8 was observed in the absence of SOCS1 (Fig. 8a-b). The gene discussed is SOCS1; the disease is hepatocellular carcinoma.