Among the eleven PI3K-AKT-MTOR pathway genes negatively correlated with SOCS1/SOCS3, all except PIK3CA and PIK3R1 showed significantly elevated expression in HCC tumors compared to normal liver tissue (Fig. 6b), and several of them also displayed significant independent predictive value, with high expression associated with poor survival (Fig. 6c). The gene discussed is SOCS3; the disease is hepatocellular carcinoma.