SQSTM1 and hepatocellular carcinoma: Furthermore, higher SQSTM1 expression was associated with higher resistance of HCC cell lines to GSK1070916 (p < 0.05), while it was associated with higher sensitivity to other drugs such as 17-AAG, Trametinib, RDEA119, PD-0325901, Selumetinib, Dasatinib, Docetaxel and Lapatinib (p < 0.05; Fig. 8c).