HDAC1 and hepatocellular carcinoma: High HDAC1 expression was associated with higher drug resistance (higher IC50) of HCC cell lines to Trametinib, 17-AAG, HG-5-113-01, Bleomycin, RDEA119, Nutlin-3a, PD-0325901, Elesclomol, CHIR-99021, Afatinib, Cetuximab and Selumetinib (p < 0.05), while it was associated with higher drug sensitivity (lower IC50) of HCC cell lines to Pyrimethamine and Methotrexate (p < 0.05; Fig. 8a).