To investigate the synergistic effects of AMPK and two pro-anabolic pathways, peroxisome proliferator-activated receptors (PPAR) and mammalian target of rapamycin (mTOR) signaling in tumor progression, we calculated PPAR and mTOR pathway scores (detailed in the methods section) for each glioma tumor. This evidence concerns the gene PRKAA1 and glioma.