However, misregulation of several RBPs, including CELF (CUG-BP, Elav-like family), MBNL (Muscleblind-like) and RBFOX (RNA-binding forkhead box) families of proteins, disrupts muscle-specific alternative splicing and has been linked to skeletal muscle disease such as myotonic dystrophy [7,54]. The gene discussed is MBNL1; the disease is myotonic dystrophy.