IRF5 and severe acute respiratory syndrome: Interestingly, in a recently published review, Laviada-Molina et al. argued that overproduction of deleterious cytokines called “cytokine storm” following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was related to the increased glucose metabolism and IRF5 triggering, leading to hyperinflammation due to a massive inflammatory gene overexpression, induction of the ER stress, and a dysregulated cytokine profile, with increased risks of vascular hyperpermeability and multiorgan failure [57].