First of all, we show that the expression of immune-metabolic transcriptional regulator IRF5 was found to be significantly upregulated in monocytes from diabetic patients compared to nondiabetic individuals and that these changes associated with the expression of hyperglycemia-induced clinical marker HbA1c and several inflammatory markers including TNF-α, IL-1β, and CCR2. The gene discussed is IRF5; the disease is Hyperglycemia.