However, while commenting on the dynamic nature of macrophage polarity and their role in the biology of adipose tissue, Kraakman et al. argue that it is important to also consider a “non-glucose/insulin resistant-centric view” with regard to role of adipose tissue macrophages and that they could contribute significantly to the risk of other associated diseases such as cardiovascular disease and cancer [73]. The gene discussed is INS; the disease is cancer.