CCL2 and Hyperglycemia: In line with our previous observations, IL-1β (Figure 2D) and MCP-1 (Figure 2E) levels were significantly elevated in supernatants from macrophages cultured under the constant hyperglycemia (IL-1β/p = 0.003; MCP-1/p = 0.001) or fluctuating hyperglycemia (IL-1β/p = 0.003; MCP-1/p = 0.001) as compared to respective normoglycemic controls.