POU5F1 and obesity due to melanocortin 4 receptor deficiency: In obesity, these cells lose their main features accompanied by a decrease in their multipotent state on account of reduced expression of pluripotency-associated genes like octamer-binding protein 4 (OCT4), SRY-Box transcription factor 2 (SOX2), homeobox transcription factor Nanog (NANOG), RNA exonuclease 1 homolog (REX1), and homeobox protein hox-C10 (HOXC10) [77,78].