Moreover, the secretion of proinflammatory cytokines like TNF-α, IL-6, and MCP-1 promotes JNK, IKK-β/NF-κB, and inducible iNOS pathways, further enhancing the inflammatory process induced by obesity, facilitating the development of insulin resistance [14,184]. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.