Next, the immune response is altered in patients with obesity and diabetes, both factors are associated with a chronic low-level inflammation [11,191], reduced NK cell activity, and deregulated numbers of CD4+ and CD8+ T cells [189], which could cause a delayed immune response and a prolonged hyperinflammation in COVID-19 patients. This evidence concerns the gene CD8A and obesity due to melanocortin 4 receptor deficiency.