SLCO1B3 and neoplasm: However, Hamada et al. [69] tested cell lines of different tumor entities for the most frequent polymorphisms, namely SLCO1B3 rs4149117 (c.334T>G, p.112S>A) and SLCO1B3 rs731135 (c.699G>A, p.M233I), showing that the linkage of these polymorphisms is conserved during malignant transformation.