Autophagy deficits are likely to contribute to neurodegeneration in various diseases [133] and enhance the aggregation of pathological proteins (Aβ peptide and Tau in AD, α-synuclein in PD, and SOD1 and TAR DNA-binding protein 43 (TDP-43) in ALS). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.