Although numerous arguments remain regarding the causative molecule for AD, Aβ or phosphorylated tau (p-tau), extensive evidence suggests that Aβ42 deposition in the brain parenchyma appears earlier than p-tau deposition in neurofibrillary tangles and can be detected in the brain many years prior to the appearance of AD clinical symptoms [13]. The gene discussed is MAPT; the disease is Alzheimer disease.