Otherwise, the administration of microbial metabolites with a predictive function can be tested, such as the treatment with a SCFAs mixture that drove to the reduction of incidence of colitis-derived CRC as well as the decrease of inflammation through the downregulation of the expression of the pro-inflammatory cytokines IL-6, IL-17, and TNF-α in mice [108]. Here, TNF is linked to colorectal carcinoma.