FLG and atopic eczema: The downregulation of miR-143 in atopic dermatitis stimulates the activity of IL-13 secreted by activated Th2 cells by targeting interleukin 13 receptor subunit α1 (IL-13Rα1), resulting in reduced expression of filaggrin and components of cornified envelope proteins such as involucrin and loricrin [12,93,94].