Hailey-Hailey disease, an autosomal dominant disorder characterized by suprabasal acantholysis, is a cornification disorder associated with mutations in the ATPase secretory pathway Ca2+ transporting 1 (ATP2C1) gene encoding intracellular calcium pumps resulting in abnormal cytosolic Ca+2 levels [42]. The gene discussed is ATP2C1; the disease is Hailey-Hailey disease.