Downregulated miR-26a-5p is also involved in barrier function of patients with atopic dermatitis [95] by targeting hyaluronan synthase 3 (HAS3), DEP domain-containing 1B (DEPDC1B), DEPDC1, nicotinamide phosphoribosyltransferase (NAMPT), DENN domain-containing 1B (DENND1B), and a disintegrin and metalloproteinase domain 19 (ADAM19), which mediate cell differentiation, cell proliferation, and anti-apoptosis. This evidence concerns the gene HAS3 and atopic eczema.