FPR2 and Alzheimer disease: The increased expression of ALX/FPR2 in patients with AD suggests enhanced neuroinflammation [134]; however, since Aβ is also a ligand for ALX/FPR2 [71], the increased expression of the receptor may either indicate a compensation for reduced concentrations of SPMs or that ALX/FPR2 transmits different signals depending on the site to which a ligand binds.