As both of these signaling cascades play essential roles in tumorigenesis [97,98], further experiments demonstrated the combination of an mTOR/AKT inhibitor (VS-5584) and a WNT/β-catenin inhibitor (IGC-001) leads to a synergistic killing effect selectively in AML with high PRL-3 expression. Here, AKT1 is linked to acute myeloid leukemia.