In a metabolism-focused library screen (361 shRNA targeting 67 genes in glycolysis and TCA cycle pathways) [24], CKMT1 was identified as necessary for the survival of AML with a high level of EVI1, a proto-oncogene whose expression level is associated with adverse prognosis in AML patients [99]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.