Figure 2 shows the pedigree of a family with VUS. The proband harboring the c.4928T > C variant in the BRCA2 gene was diagnosed with breast cancer at the age of 39; her mother suffered from bilateral BC and carried the same VUS. Her aunt (mother’s sister) died of breast cancer as did her grandmother (BRCA test not performed). Here, BRCA2 is linked to breast cancer.