Blocking PFKFB3 by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) can negatively regulate glycolysis and modulate rat sarcoma viral proto-oncogene (Ras) and protein kinase B (AKT) in HER2+ BC cells [56]. Here, AKT1 is linked to breast cancer.