We described also a 13-year-old girl with NS associated with a recurrent mutation in <i>PTPN11</i>, who developed three different types of brain tumors, i.e., an optic pathway glioma, a glioneuronal neoplasm of the left temporal lobe and a cerebellar pilocytic astrocytoma. This evidence concerns the gene PTPN11 and cerebellar pilocytic astrocytoma.