Another way Ph+ B-ALL cells avoid negative selection is the expression of surface inhibitory receptors such as platelet endothelial cell adhesion molecule 1 (PECAM1), CD300A, and leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), which recruit the inhibitory phosphatase SHIP1, calibrating the strength of BCR-ABL1 signaling. The gene discussed is LAIR1; the disease is acute lymphoblastic leukemia.