Energy stress sensor protein, 5′AMP-activated protein kinase (AMPK) has been identified as mediator of IKZF1 and PAX5 effect on cell metabolism, as its pharmacological inhibition in Ph+ B-ALL cells caused similar effects as reconstitution of those transcription factors, causing energy depletion and cell death [13]. Here, IKZF1 is linked to acute lymphoblastic leukemia.