Knockdown of PP2A or its pharmacological inhibition lowered NADPH levels, reduced expression of antioxidant genes (e.g., catalase, CAT; superoxide dismutase 2, SOD2; peroxiredoxin 2/4, PRDX2/4), increased reactive oxygen species (ROS), and resulted in apoptosis of Ph+ B ALL cells. The gene discussed is PRDX2; the disease is acute lymphoblastic leukemia.