Other studies have shown that combined phosphorylation of γ-catenin by BCR-ABL1 and LYN kinase, both of which are essential in Ph+ B-ALL, promotes expression and transactivation of MYC oncogene, another key player of BCR-ABL1-driven leukemia initiation and propagation in B cell progenitors [163]. The gene discussed is MYC; the disease is acute lymphoblastic leukemia.