A genetic study of 97 Ph+ B-ALL patients revealed recurring alterations in the following genes: B-cell translocation gene 1 (BTG1; 18%), retinoblastoma protein 1 (RB1; 14%), early B-cell factor 1 (EBF1; 13%) and translocation-Ets-leukemia virus (ETV6; 5%) [56]. Here, EBF1 is linked to acute lymphoblastic leukemia.