Even though CML in CP is now a manageable disease, in up to 5–10% of cases it progresses to more aggressive AP and finally to a fatal BP, either of myeloid (MBP) or lymphoid (LBP) lineage (70% and 30% of cases, respectively [31]). This evidence concerns the gene LBP and chronic myelogenous leukemia, BCR-ABL1 positive.