BCR and acute lymphoblastic leukemia: Another way Ph+ B-ALL cells avoid negative selection is the expression of surface inhibitory receptors such as platelet endothelial cell adhesion molecule 1 (PECAM1), CD300A, and leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), which recruit the inhibitory phosphatase SHIP1, calibrating the strength of BCR-ABL1 signaling.