Novel B lineage-specific vulnerabilities and putative therapeutic targets identified over the last decade are summarized in Figure 2A. One of the major molecular differences between CML and Ph+ B-ALL is the preferential occurrence of the longer, p210 BCR-ABL1 variant in CML, and the shorter, p190 variant in Ph+ B-ALL. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.