In addition to having the capacity to decrease TNF-α protein levels and the tendency to reduce the oxidized proteins, FRB supplementation was also shown to reduce the NF-κB phospho-p65/p65 ratio in comparison with STZ treatment alone, further confirming that FRB supplementation reduced the activation of the NF-κB pathway that occurred due to STZ-induced diabetes. The gene discussed is FOLR2; the disease is diabetes mellitus.