FOXO family proteins play a vital role in the development of muscle atrophy by activating the ubiquitin-mediated proteolysis pathways including the regulation of FBXO32/Atrogin-1 and TRIM63/MuRF1 [40], and dependently regulate BNIP3L and GABARAPL1 in a STZ-diabetes model [4]. Here, BNIP3L is linked to diabetes mellitus.