RECK is silenced by DNMT3b-mediated promoter methylation in lung cancer cells in which RECK suppresses invasiveness [97] and inversely correlates with lymph node metastasis in NSCLC [98], PDAC (pancreatic ductal adenocarcinoma) [99], osteosarcoma [100], esophageal [101], and breast cancer [102]. The gene discussed is DNMT3B; the disease is breast cancer.