In particular, BRMS1 (breast cancer metastasis suppressor 1)—which inhibits breast (but also ovarian, melanoma, NSCLC, and bladder) cancer, in addition to cancer metastasis without affecting in vitro and in vivo tumor growth—participates to the mSin3 histone deacetylase transcriptional repressor complex. This evidence concerns the gene BRMS1 and neoplasm.