In particular, BRMS1 (breast cancer metastasis suppressor 1)—which inhibits breast (but also ovarian, melanoma, NSCLC, and bladder) cancer, in addition to cancer metastasis without affecting in vitro and in vivo tumor growth—participates to the mSin3 histone deacetylase transcriptional repressor complex. The gene discussed is BRMS1; the disease is urinary bladder carcinoma.