THBS1 and neoplasm: The tumor suppressor genes silenced by aberrant promoter hypermethylation encode a wide range of protein products, including cell cycle inhibitors (INK4A/p16 and Rb), DNA repair factors, detoxifying enzymes (GSTP1, glutathione S-transferase Pi 1), angiogenesis inhibitors (VHL, Von Hippel–Lindau tumor suppressor and THBS1, thrombospondin 1), cell–cell adhesion receptors (CDH1, cadherin-1), metalloprotease inhibitors (TIMP3, tissue inhibitor of metalloproteinases 3), and many others [45,46].