In hepatic carcinogenesis, among 369 differentially methylated enhancers, a key role is played by the recurrently hypomethylated enhancer of CEBPB (encoding for C/EBPbeta, CCAAT/enhancer-binding protein beta), representing a major driver of global transcriptional reprogramming in Hepatocellular carcinoma (HCC) tumor progression [17]. This evidence concerns the gene CEBPB and hepatocellular carcinoma.