Nitrate/nitrite treatment also improved glucose intolerance in eNOS−/− mice [21,56], reduced fasting blood glucose in db/db mice [42], rescued glucose intolerance and HOMA-IR in diabetic KKAy mice [43], and reversed insulin levels with improvement in GTT and PTT in HFD fed diabetic rats [57]. The gene discussed is INS; the disease is Glucose intolerance.