Both of the APC coactivators have tumor related functions; CDC20 is a well-known oncogene which drives improper cell proliferation [36, 49, 72–74], while CDH1 is considered a tumor suppressor that regulates mitotic exit, entrance to S phase, induces quiescence under stress conditions and maintains genomic stability [16, 66, 75, 76]. This evidence concerns the gene APC and neoplasm.