However, the observation that overexpression of CDC20 is accompanied by the overexpression of a host of other genes associated with APC impairment in other cancers [37], including overexpression of other APC substrates (Figure 4), indicates that it may be APC impairment, not specifically CDC20 overexpression, that is important for cancer development and/or progression, in at least some cases. Here, CDC20 is linked to cancer.