Polo-like kinase 1 (PLK1) is a serine/threonine kinase that is implicated in tumorigenesis and serves as a prognostic marker for worsened patient outcomes in multiple cancers, including non-small cell lung cancer (NSCLC) [201], head and neck squamous cell carcinomas [202], and breast cancer [48, 203, 204]. The gene discussed is PLK1; the disease is head and neck squamous cell carcinoma.