FOXM1 and gastric cancer: By driving the synthesis of SCF components (SKP2 and CKS1), FOXM1 initiates its own destruction, as 2 different SCF complexes, SCFFBXL2 and SCFFBXO31, target FOXM1 for degradation, with SCFFBXO31 specifically targeting FOXM1 at the G2/M boundary and SCFFBXL2 targeting FOXM1 in gastric cancer cells [242, 243].