IRF5 and systemic lupus erythematosus: Of note, our analysis did not capture the known association between the PAS SNP in the 3’UTR of IRF5 and risk for SLE [25], because this locus likely contains several causal variants that act through different mechanisms, some of which have a stronger effect on IRF5 expression and SLE risk than the PAS pA-QTL (S4 Fig).