MeSH-based disease analysis demonstrated that significant changes in cardiomyocyte genes (decreased MYL2 and MYH6 and increased RYR2, HCN4, CORIN, NPPA, ERBB2, and MYH7) in LV of obese ZSF1 rats were strongly associated with dilated cardiomyopathy, LV hypertrophy, and HF (Fig 5F), and were similar to those observed in human genetic studies [59]. The gene discussed is HCN4; the disease is dilated cardiomyopathy.