The reciprocal relationship between systemic aldosterone and NT-proBNP was recently reported in a human CMS populational study (n = 1674; age ≥ 45 years) [34], where the authors demonstrated strong (p < 0.001) association of aldosterone increase with hypertension, obesity, chronic kidney disease, metabolic syndrome, high triglycerides, concentric LV hypertrophy, and atrial fibrillation. The gene discussed is NPPB; the disease is metabolic syndrome.