BGN and preterm premature rupture of the membranes: Thus, the aims of this study were threefold: (1) to define the natural course of serum decorin and biglycan throughout the duration of healthy pregnancy, (2) to explore patterns of serum decorin and biglycan expression in serum of asymptomatic women who go on to develop spontaneous preterm labor, and (3) to investigate the potential role for matrix metalloproteinases, their inhibitors, and collagen VI in a serum-based screening model to predict PPROM.