The protein GAS-1 was elevated in our model of mTBI; it is interesting that Wang and co-workers illustrated that GAS-1 protein levels were up-regulated in vitro by challenge with glutamate and that elevated levels of GAS-1 protein may interfere with the protective effects of glial cell neurotrophic factor (GDNF, Wang et al., 2016a). The gene discussed is GDNF; the disease is concussion.