CXCL16 and brain injury: Of these three proteins GAS-1 and CXCL16 may be the best options for drug target validation, both proteins are known to modulate neuronal cell death involving glutamate excitotoxicity, a common feature of brain injuries (Globus et al., 1995; Mellström et al., 2002; Rosito et al., 2012; Rosito et al., 2014; Sun et al., 2016; Wang et al., 2016a; Zarco et al., 2012) and as such may make them ideal candidate drug targets for evaluation.