Fifteen of the altered proteins mapped to 12 different pathways: pathological pathways included Apoptosis signaling pathway (P00006, FASL, Granzyme B), FAS signaling pathway (P00020, FASL) and Alzheimer disease-presenilin pathway (P00004, E-Cadherin). Here, GZMB is linked to early-onset autosomal dominant Alzheimer disease.