Twelve different proteins significantly altered by 48 hr after mTBI mapped to 11 different functional pathways, pathological pathways were: Apoptosis signaling pathway (P00006, FASL, TNF-R2), FAS signaling pathway (P00020, FASL) and Alzheimer disease-presenilin pathway (P00004, E-Cadherin, MMP-9). Here, MMP9 is linked to early-onset autosomal dominant Alzheimer disease.