ACVR1 and atrial septal defect: Bmp4 is expressed in the DMP (Briggs et al., 2016; Burns et al., 2016; Sun et al., 2015; Briggs et al., 2013) and mutations in BMP4 and the BMP receptor Alk2 have been implicated in atrial septal defects and AVSDs (Smith et al., 2011).