Sugar consumption often exceeds the recommended level of 10% of the total energy intake in children and adults,13 and the excess sugar in foods or sweetened beverages and noncaloric sweeteners have been associated with glucose intolerance;5 high postprandial insulin peaks;14 and an increased risk of metabolic syndrome, diabetes,15 obesity,16 and cardiovascular disease, among others. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.