In this respect, we recently provided an all-atom model ofthe human α7 full-length (TMD+LBD) nicotinic receptor, builtby a homology model based on high-resolution X-ray templates.12 α7 is a homopentameric channel widelyexpressed in the human brain, involved in regulation of synaptic plasticityand neuronal growth, and related to schizophrenia, Alzheimer’sdisease, and even cancer development.13,14 Of utmostimportance, very recently, α7 has been considered among thenAChRs likely implicated in interaction with SARS-CoV-2 related Covid-19desease.15 This evidence concerns the gene IGKV2D-24 and cancer.