In BDNF‐enhanced migration of chondrosarcoma, integrin β5 expression was up‐regulated through TrkB/AKT signalling cascade, while in BDNF‐mediated migration of microvascular endothelial cells, the up‐expression of integrin β3 was made via TrkB/ERK1/2 pathway.14, 21. The gene discussed is AKT1; the disease is chondrosarcoma.