OXT and Huntington disease: Thermoregulatory disorders as hypothermia, erratic thermogenesis, and an abnormal circadian temperature rhythm have already been reported in HD,16 so the trouble tolerating cold/heat complained by our patients may be explained by both metabolic factors, as low body weight, energy expenditure due to dyskinesias and adipose tissue composition, and hypothalamic pathology characterized by oxytocin and vasopressin neuron loss.16