Treating melanoma cells for 3 weeks with pro-adipogenic-differentiating medium, we observed a higher trans-differentiation ability of acid-adapted cells compared with control cells, assessed via qPCR analysis of the adipogenic markers LPL, CEBPα, and PPARγ, and via Oil Red O staining of intracytoplasmic lipid drops (Fig. 6b). Here, CEBPA is linked to melanoma.