The patient was a 49-year-old woman with unifocal, grade 3, triple-negative (estrogen receptor weakly positive [Allred score, 3; 5% positive cells], progesterone receptor-negative, human epidermal growth factor receptor type 2–negative [score, 1+]) invasive carcinoma of no specific type in the right breast (upper inner quadrant) and a Ki67 result of 90% positive cells with no necrosis at biopsy. This evidence concerns the gene ESR1 and invasive carcinoma.