OI type III samples showed a greater upregulation in TWIST1, BGLAP, and RUNX2 with treatment, whereas OI type III/IV had a greater magnitude of upregulation for WISP1, SOST, and COL1A1. OI type IV samples showed the greatest upregulation in DKK1 and SP7, and a comparable response in BGLAP for OI type III patients. Here, CCN4 is linked to osteogenesis imperfecta type 3.