Indeed, Pompe disease (due to a deficiency of acid alpha-1,4-glucosidase, GAA) and mucopolysaccharidosis type I (MPS I, due to a deficiency of alpha-L-iduronidase, IDUA) have already been added to the US Secretary of Health and Human Services’ Recommended Uniform Screening Panel (RUSP) [1]. This evidence concerns the gene GAA and Scheie syndrome.