TP53 and breast carcinoma: Among the entire cohort (Fig. 1a), luminal (Fig. 1b) or luminal/ductal subtypes (Fig. 1c), p53 mutations were observed at a significantly higher frequency in breast cancers from the lower quintile compared to the highest quintile MD group (24% versus 6%, p = 0.0499; 22% versus 0%, p = 0.0058; and 21% versus 0%, p = 0.0390, respectively).