TP53 mutant cancers were compared to TP53 wild-type cancers in the lowest quintile of MD and showed a significantly higher mean HRD sum score (mean score 49.0 versus 30.2, p = 0.0306, Fig. 2j) and FGA (mean score 0.47 versus 0.31, p = 0.0213, Fig. 2k). The gene discussed is TP53; the disease is cancer.