When IgHVmut and IgHVunmut patients were evaluated separately, in both groups, a higher proportion of CLL cells positive on CXCR3 (in both P < 0.001) and lower expression of CXCR4 (in both P < 0.001) was observed on CD5high subpopulation in comparison with CD5low cells (Figure 3(b)). Here, CXCR4 is linked to B-cell chronic lymphocytic leukemia.