Interestingly, after enrichment analysis of disease-associated metabolite sets, the metabolites were highly enriched for disease categories relating to neonatal intrahepatic cholestasis, ornithine transcarbamylase deficiency, schizophrenia, acute seizures, refractory localization-related epilepsy, propionic acidemia, and different seizure disorders (p < 0.05), which implied deterioration of liver metabolism in septic patients (Figure 2(d), Supplementary Excel file: S table 1D). This evidence concerns the gene OTC and epilepsy.