As a result, 8 genes with p value <0.05 as well as AUC >0.80 showed excellent diagnostic value for rheumatoid arthritis, and thus were considered as hub genes of RA, including CCR5, CCL5, CXCL9, CXCL10, CXCL13, PNOC, TLR8, and CD52. This evidence concerns the gene CCL5 and rheumatoid arthritis.