TLR8 and rheumatoid arthritis: As a result, 8 genes with p value <0.05 as well as AUC >0.80 showed excellent diagnostic value for rheumatoid arthritis, and thus were considered as hub genes of RA, including CCR5, CCL5, CXCL9, CXCL10, CXCL13, PNOC, TLR8, and CD52.