Then, a behavioral evaluation suggested that ICA treatment at 100 mg/kg/d had a similar analgesic effect as that of reparixin treatment, an inhibitor of CXCR1/2, which is the primary receptor responding to CINC-1/IL-8, suggesting that inhibition of CINC-1 may be the mechanism by which ICA alleviated LBP (Figure 5(a)). Here, CXCR1 is linked to Low back pain.