In our investigation, we examined the TIGIT expression on Foxp3+ γδ T cells in AML patients of different clinical statuses for the first time and observed that the proportions of Foxp3+ γδ T cells and TIGIT+Foxp3+ γδ T cells were increased in both de novo AML and AML-NR patients. Here, FOXP3 is linked to acute myeloid leukemia.