Compared to HF patients without T2DM, the NPPB coexpression genes were enriched in several other pathways, such as arrhythmogenic right ventricular cardiomyopathy (ARVC), dilated cardiomyopathy, hypertrophic cardiomyopathy (HCM), cardiac muscle contraction, alcoholism, and the PI3K-Akt signaling pathway. Here, AKT1 is linked to type 2 diabetes mellitus.